Testimonials and Case Studies
Hubrecht Organoid Technology
HUB (Hubrecht Organoid Technology) in Utrecht, Netherlands.
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The focus of organoid research was initially also on cultivating healthy cells, with the ultimate goal of regenerative medicine and cell therapy. In the meantime, the attention has switched to preclinical drug screening and diagnostics and, by extension, personalised medicine. ‘In any case, the road to cell therapy is very long, even longer (and also more uncertain) than the road to launching medicines on the market based on small molecules. However, we noticed that we could grow not only healthy cells but diseased cells as well, such as cancer cells. That opened the door to applications that can be developed a lot faster, for example disease modelling by growing organoids directly from diseased patient tissue. Furthermore, direct cloning of multiple individual cells from primary tumours enabled molecular and functional analysis of tumour heterogeneity. And we can also work with CRISP-mediated genome modification. Human organoids appear to be very receptive to this, which offers an enormous range of possibilities in modelling of malignant transformation and mutagenesis after defect DNA. repair.’