Cryogenic Storage Innovations Lead to Safer Biological Samples

Cryogenic freezers store irreplaceable biological samples that are essential in providing data to validate or otherwise inform experimental therapy research. PHCbi brand cryogenic freezers offer a safer way to protect those samples.

When samples are stored at or below -130°C, known as the glass transition temperature of water, metabolic activity in the cell is suspended indefinitely.i As long as samples are properly prepared, frozen, and kept at stable storage temperatures, this ensures their continued viability. However, temperature variations during cryogenic storage can lead to massive cell death, rendering samples unusable.ii

In a recent SelectScience® editorial article, "Cryogenics, cancer & COVID-19: Transitioning from liquid to air phase cryogenic storage," an expert panel discussed the importance of reliable cryogenic storage for novel research projects in a variety of areas. Panelists shared the challenges they face as well as their hopes for the future. According to the panel, one of the biggest issues is sample loss. However, cryogenic technology advances that provide highly reliable storage can give hope.

An Innovation in Cryogenic Storage – Air Phase Storage Medium

The PHCbi brand MDF-C2156VANC-PA, -150°C Cryogenic Freezer, is a safe, reliable, and economical solution that creates air phase cryogenic storage. Air phase cryogenic storage offers an alternative to reliance upon LN2, minimizes total storage costs, and decreases safety concerns. Energy efficiency in our cryogenic freezers is achieved through balanced temperature performance and power management, making them an economical choice when replacing existing liquid nitrogen freezers or installing new long-term product storage systems. Additionally, the innovative PHCbi brand -150°C cryogenic freezer minimizes the possibility of cross contamination among multiple samples in cryogenic storage by eliminating vial damage caused by pulldown or other processes.

Read the full article Editorial Article: Cryogenics, cancer & COVID-19: Transitioning from liquid to air phase cryogenic storage on SelectScience.


iASHRAE Handbook, Applications, ©1978, American Society of Heating, Refrigerating and Air Conditioning Engineers, Inc, Chapter 53, Biomedical Applications.
iiSelectScience. "Transitioning from Liquid to Air Phase Cryogenic Storage." SelectScience. Accessed November 17, 2022.